23dihydro1Hindol2one

23dihydro1Hindol2one is a heterocyclic organic compound in the indolinone family. It represents the dihydro derivative of 1H-indol-2-one, produced by hydrogenation of the indole’s 2-3 bond. The core consists of a benzene ring fused to a five-membered lactam ring bearing a carbonyl at position 2. The saturated ring context distinguishes it from the fully aromatic parent indole.

Synthesis and occurrence are primarily discussed in the context of organic synthesis and medicinal chemistry. It can be prepared by catalytic hydrogenation of 1H-indol-2-one substrates or by reduction of related indoline-2-one precursors. In practice, variations in substitution on the nitrogen or at the 3- and 4- positions can lead to a family of dihydroindol-2-one derivatives, all sharing the same core scaffold but differing in reactivity and functionalization potential.

Properties and applications are mainly those associated with the indolinone framework. The non-aromatic, partially saturated core provides a versatile platform for chemical diversification, enabling subsequent functionalization at the nitrogen and on the ring system. Compounds based on the indolinone motif have been explored as intermediates in organic synthesis and as scaffolds in medicinal chemistry, where related derivatives have been investigated for biological activity such as enzyme inhibition and anticancer potential. The 23dihydro variant serves as a structural starting point for developing more complex molecules.

See also: indolinone, indole, 1H-indol-2-one, isatin, indoline.