17alkylated

17-Alkylated is a term used in the context of steroid hormones, particularly in the field of anabolic-androgenic steroids. These compounds have an alkylation at the 17th carbon atom, which is a key modification that affects their physiological activity.

The alkylation at the 17th carbon atom is typically achieved by replacing the hydrogen atom at this position with an alkyl group, usually ethyl or methyl. This modification can significantly alter the pharmacokinetics and pharmacodynamics of the steroid, including its binding affinity to the androgen receptor, its ability to induce anabolism, and its potential for androgenic side effects.

17-Alkylated steroids are often more potent and have longer duration of action compared to their 17α-methyl analogs, but they also tend to have a higher potential for toxic effects, such as liver damage, due to their increased metabolism by the liver. This increased toxicity is thought to be related to the strengthened affinity of these compounds for the liver enzyme, CYP3A4, which is responsible for their metabolism.

The use of 17-Alkylated steroids has been largely discontinued in modern clinical settings due to the availability of safer and more effective alternatives. However, they continue to be used off-label by some bodybuilders and athletes seeking to enhance their physical performance. The use of these compounds should be approached with caution, as their potential for harm and abuse is well-documented.