141residue

141residue refers to a specific class of proteins or peptides that consist of exactly 141 amino acid residues. This length is commonly encountered in structural biology, where the compact size allows for high-quality crystallographic or cryo‑electron microscopy studies. Many 141-residue proteins function as monomeric enzymes, DNA‑binding domains, or structural subunits within larger macromolecular complexes.

The 141‑residue length often corresponds to a well‑defined secondary‑structure motif. For instance, some transcription factors contain a 141‑residue zinc‑finger domain that mediates DNA recognition, while others comprise a 141‑residue α‑helix bundle that serves as a hinge in signaling pathways. The uniformity of this size facilitates comparative analyses; researchers can align the sequences of different 141‑residue proteins to identify conserved residues that are critical for catalytic or binding activity.

In addition to natural proteins, synthetic peptides of 141 residues are produced for vaccine design and peptide‑based therapeutics. Their moderate size allows efficient synthesis and purification while retaining biological activity. Because 141 residues is small enough for most expression systems yet large enough to form stable tertiary structures, the 141residue motif has become a popular template for protein engineering projects.