ubiquitinázás
Ubiquitinázás refers to the process of ubiquitination, a crucial post-translational modification in all eukaryotic cells. It involves the covalent attachment of a small protein called ubiquitin to a target protein. This process is highly regulated and carried out by a cascade of enzymes. First, an activating enzyme (E1) uses ATP to bind ubiquitin. Then, a conjugating enzyme (E2) accepts the activated ubiquitin from E1. Finally, a ligase enzyme (E3) specifically recognizes the target protein and facilitates the transfer of ubiquitin from E2 to the target.
Ubiquitination can occur as a single ubiquitin molecule (monoubiquitination) or as a chain of ubiquitin molecules
This degradation pathway, known as the ubiquitin-proteasome system (UPS), plays a vital role in maintaining cellular