tumorinfiltrerende

Tumorinfiltrerende refers to the process by which tumor cells invade surrounding tissues. This phenomenon is a critical hallmark of malignancy and is central to the development of metastasis. When tumor cells detach from the primary tumor mass, they gain the ability to break down the extracellular matrix and the basement membrane that separates them from adjacent healthy tissues. This degradation is often facilitated by enzymes secreted by the tumor cells, such as matrix metalloproteinases.

Once these barriers are breached, tumor cells can then migrate into the surrounding stroma, blood vessels, or lymphatic channels. This infiltration allows cancer to spread locally, potentially affecting nearby organs and structures. The degree of tumor infiltration is an important prognostic factor, as it often correlates with the aggressiveness of the cancer and the likelihood of recurrence or spread. Pathologists assess the extent of infiltration during tissue analysis to help determine the stage of the cancer and guide treatment decisions. Understanding tumor infiltration is crucial for developing therapies that can prevent or reverse this invasive process.