tSNAREek

tSNAREek is a protein that plays a crucial role in intracellular membrane trafficking. It belongs to the SNARE (Soluble NSF Attachment Protein Receptor) family, a group of proteins that mediate the fusion of vesicles with target membranes. Specifically, tSNARE stands for target SNARE, indicating its function in binding to vesicles that carry cargo to their destination. These SNARE proteins are essential for processes such as neurotransmitter release, protein secretion, and organelle function.

The mechanism involves the formation of a SNARE complex, where tSNARE proteins on the target membrane interact with v-SNAREs (vesicle SNAREs) on the surface of transport vesicles. This interaction leads to the docking and subsequent fusion of the vesicle with the target membrane, releasing its contents. tSNAREek is involved in the transport of various molecules and the maintenance of cellular organization. Its precise role can vary depending on the cellular context and the specific type of vesicle trafficking pathway it participates in. Dysregulation of tSNAREek function has been linked to several cellular defects and diseases.