sumoylationowego
Sumoylation is a type of post-translational modification in which a small ubiquitin-like protein called small ubiquitin-like modifier (SUMO) is covalently attached to a lysine residue of a target protein. This process is mediated by a family of enzymes known as SUMO ligases, which catalyze the formation of an isopeptide bond between the carboxyl group of a SUMO molecule and the amino group of a lysine residue on the target protein. The SUMO protein can be attached to the target protein in a linear or branched manner, and multiple SUMO molecules can be attached to a single target protein, forming a SUMO chain.
Sumoylation plays a crucial role in various cellular processes, including gene transcription, DNA repair, protein degradation,
The SUMO modification is a highly dynamic process, with SUMO molecules being rapidly attached and detached