stopkodonerne
Stopkodonerne (stop codons) are the three codons that mark the end of translation in most organisms. In the standard genetic code they are UAA, UAG, and UGA in messenger RNA, corresponding to the DNA codons TAA, TAG, and TGA. These codons terminate the coding sequence and signal the ribosome to release the completed polypeptide.
Termination is mediated by release factors. In bacteria, RF1 recognizes UAG and UAA while RF2 recognizes UGA
Variations and exceptions exist. Some organelles and organisms use alternative genetic codes, and certain codons can
Clinical relevance is significant. Premature stop codons, or nonsense mutations, truncate proteins and underlie many genetic