snRNPkompleksit

snRNPkompleksit, often referred to as snRNPs (pronounced "snurps"), are crucial components of the spliceosome, the molecular machinery responsible for pre-messenger RNA (pre-mRNA) splicing in eukaryotes. Each snRNP is a complex particle composed of a small nuclear RNA (snRNA) molecule and a set of associated proteins. There are five main types of snRNPs involved in splicing: U1, U2, U4, U5, and U6. These snRNPs recognize specific sequences within the pre-mRNA, including the 5' splice site, the branch point, and the 3' splice site, guiding the splicing process. The snRNAs within the snRNPs provide the structural framework and catalytic activity, while the proteins are involved in RNA binding, assembly, and regulation of spliceosome function. The sequential assembly of these snRNPs onto the pre-mRNA molecule forms the dynamic spliceosome, which undergoes conformational changes to accurately excise introns and ligate exons. Defects in snRNP composition or function can lead to aberrant splicing, resulting in non-functional proteins and contributing to various human diseases.