renininhibitorok

Renin inhibitors are a class of drugs used to treat high blood pressure, also known as hypertension. They work by directly blocking the action of renin, an enzyme produced by the kidneys. Renin is the first and rate-limiting step in the renin-angiotensin-aldosterone system (RAAS), a hormonal cascade that plays a crucial role in regulating blood pressure and fluid balance. When renin is inhibited, the production of angiotensin I, angiotensin II, and aldosterone is reduced. Angiotensin II is a potent vasoconstrictor, meaning it narrows blood vessels, which increases blood pressure. Aldosterone promotes sodium and water retention, further contributing to elevated blood pressure. By inhibiting renin, these drugs lead to vasodilation (widening of blood vessels) and reduced sodium and water retention, thereby lowering blood pressure. Aliskiren is the primary example of a direct renin inhibitor currently available for therapeutic use. It is typically prescribed for individuals with hypertension who may not have achieved adequate blood pressure control with other antihypertensive medications or in combination therapy. Like all medications, renin inhibitors can have side effects, which may include diarrhea, cough, and angioedema. Their use should be supervised by a healthcare professional.