psoraleenilääke

Psoraleenilääke is a classification of drugs used in photochemotherapy, primarily for the treatment of various skin conditions. These medications are a type of psoralen, which are naturally occurring compounds found in plants. When psoralen-based drugs are administered, either orally or topically, they make the skin more sensitive to ultraviolet A (UVA) light. This combination of psoralen and UVA light is known as PUVA therapy.

The mechanism of action involves psoralen molecules intercalating into the DNA of skin cells. Upon exposure to UVA radiation, these molecules become activated and form covalent cross-links within the DNA strands. This process inhibits the proliferation of rapidly dividing cells, such as those found in psoriatic plaques and eczema. The DNA damage also triggers an inflammatory response that can further aid in clearing the skin condition.

Psoraleenilääkkeitä are most commonly prescribed for moderate to severe cases of psoriasis. They are also used to treat eczema, vitiligo, and cutaneous T-cell lymphoma. The treatment typically involves a course of sessions, usually a few times a week, under medical supervision to ensure safe and effective exposure to UVA light. Due to potential side effects, such as increased risk of skin cancer with long-term use and acute phototoxicity, psoralenilääkkeitä are generally reserved for cases that have not responded well to other therapies. Careful monitoring by a dermatologist is crucial throughout the treatment period.