prostaglandiini
Prostaglandiini, in Italian usage referring to prostaglandins, are a group of physiologically active lipid compounds known as eicosanoids. They are derived from arachidonic acid and are produced by nearly all body tissues, where they act as local mediators to regulate a wide range of biological processes. Prostaglandins are classified into several families, including prostaglandin E (PGE), D (PGD), F (PGF), I (prostacyclin, PGI), and thromboxane A2 (TXA2), each with multiple subtypes that reflect their tissue-specific roles.
Biosynthesis occurs when phospholipase A2 releases arachidonic acid from membrane phospholipids. Cyclooxygenases (COX-1 and COX-2) convert
Physiological and clinical roles of prostaglandins are broad. They participate in inflammation, fever, and pain signaling;
Pharmacologically, prostaglandin synthesis is targeted by NSAIDs, which inhibit COX enzymes and reduce prostaglandin production. Prostaglandin