prealbuminës

Prealbumin, also known as transthyretin (TTR), is a protein primarily synthesized in the liver. It plays a crucial role in transporting two key substances in the bloodstream: thyroxine (T4), a thyroid hormone, and retinol (vitamin A), bound to retinol-binding protein (RBP). Prealbumin is a relatively small protein, consisting of four identical subunits. Its half-life in the circulation is short, approximately two days, which makes it a sensitive indicator of nutritional status, particularly protein deficiency. Low levels of prealbumin can suggest malnutrition, liver disease, or inflammatory conditions. Conversely, elevated levels are less common and can be associated with certain genetic mutations or kidney disease, where the protein is not cleared effectively. The presence of prealbumin in cerebrospinal fluid also contributes to the transport of thyroid hormones within the central nervous system. While its name suggests it precedes albumin in certain contexts, its primary function is not directly related to the transport roles of albumin. Its significance in clinical settings lies in its rapid turnover and sensitivity to changes in protein synthesis and degradation.