polülaaktidkopolüglükoolhape

Polylactidkopolüglükoolhape (PLGA, poly(lactic-co-glycolic acid)) is a biodegradable and bioresorbable polymer used in various fields, including medicine and research. This synthetic copolymer is composed of two monomers: lactic acid and glycolic acid, which are derived from renewable resources. The ratio of lactic acid to glycolic acid can vary, depending on the desired properties of the final product.

PLGA is known for its solubility in common organic solvents and its ability to form films, fibers, and other structures. It has been widely used as a scaffold in tissue engineering, allowing for the growth and differentiation of cells in vitro. PLGA can also be used as a biocompatible and biodegradable implant material, due to its ability to degrade through hydrolysis, producing lactic acid and glycolic acid as byproducts.

The mechanical properties of PLGA can be tailored by adjusting the molecular weight and polymer composition. This biopolymer has been studied for its potential use in drug delivery systems, including microspheres, nanoparticles, and implantable devices. The controlled release of therapeutic agents from PLGA-based systems has been explored for the treatment of various diseases, including cancer and arthritis.

PLGA-based products have been approved by regulatory agencies for human use in many countries. However, its degradation rate and polymer composition can vary, affecting the final product's performance. Further research is necessary to fully understand the long-term effects and limitations of PLGA-based materials in medical applications.