pleuromutilinbased
Pleuromutilin-based refers to a class of antibiotics derived from pleuromutilin, a natural product isolated from the fungus *Pleurotus mutilus*. These antibiotics function by inhibiting bacterial protein synthesis. Specifically, they bind to the 50S ribosomal subunit, interfering with the peptidyl transferase center and preventing the formation of peptide bonds. This mechanism of action is distinct from many other antibiotic classes, which can be advantageous in overcoming existing resistance mechanisms.
The pleuromutilin scaffold is a tetracyclic diterpene structure. Modifications to this core structure have led to
Resistance to pleuromutilin-based antibiotics can arise through mutations in the ribosomal RNA genes or ribosomal proteins