plazmin
Plazmin, a spelling variant sometimes used in reference materials, most often refers to plasmin, a principal serine protease of the fibrinolytic system. Plasmin catalyzes the breakdown of fibrin within blood clots, contributing to clot dissolution and the restoration of normal blood flow after vascular injury. The enzyme is formed from its inactive zymogen, plasminogen, which circulates in the blood and binds to fibrin in clots.
Activation occurs when plasminogen is cleaved by plasminogen activators such as tissue-type plasminogen activator (tPA) or
Biochemically, plasmin belongs to the peptidase family S1 and operates as a catalytic serine protease. Its
Clinical relevance includes the use of plasminogen activators in thrombolytic therapy to treat pathologic clots in