plasminogen2

Plasminogen2 is a protein-coding gene located on chromosome 11 in humans. It is a member of the plasminogen family, which includes plasminogen1 and plasminogen3. The gene encodes plasminogen, a single-chain zymogen that is converted to the active enzyme plasmin by tissue-type plasminogen activator (tPA). Plasmin plays a crucial role in the fibrinolytic system, which is responsible for dissolving blood clots.

Plasminogen2 is expressed in various tissues, including the liver, kidney, and placenta. It is also found in the circulation, where it is converted to plasmin by tPA. The primary function of plasmin is to degrade fibrin, the main component of blood clots, thereby facilitating clot dissolution and preventing excessive clot formation.

Mutations in the plasminogen2 gene have been associated with an increased risk of thrombosis, a condition characterized by the formation of abnormal blood clots. This is due to the reduced activity of plasmin, which leads to impaired clot dissolution. Additionally, plasminogen2 deficiency has been linked to an increased risk of venous thromboembolism, a condition that includes deep vein thrombosis and pulmonary embolism.

In summary, plasminogen2 is a gene that encodes plasminogen, a key component of the fibrinolytic system. Mutations in this gene can lead to an increased risk of thrombosis and venous thromboembolism. Further research is needed to fully understand the role of plasminogen2 in these conditions and to develop potential therapeutic strategies.