piperacilina
piperacilina, also known as piperacillin, is a broad‑spectrum penicillin derivative used primarily in combination with beta‑lactamase inhibitors such as tazobactam. The combination, piperacillin‑tazobactam, is marketed as Zosyn among other trade names. It belongs to the fourth‑generation penicillins and exhibits activity against gram‑positive cocci, gram‑negative rods, and anaerobes.
The drug was first synthesized in the late 1970s by the pharmaceutical company Pfizer and received approval
Chemical features of piperacillin include a β‑lactam ring fused to a thiazolidine ring and a side chain
The antibacterial spectrum encompasses Enterobacteriaceae (escherichia coli, klebsiella pneumoniae), pseudomonas aeruginosa, archaea, staphylococcus aureus, streptococcus species,
Typical dosing for adults is 2 to 4 grams of piperacillin given every 6 hours, or 2