p400Tip60

p400Tip60 refers to a specific subunit of the Tip60 chromatin remodeling complex. The Tip60 complex, also known as KAT5 complex or NuA4 complex, is a multi-subunit protein complex involved in the regulation of gene transcription and DNA repair. It possesses intrinsic histone acetyltransferase (HAT) activity, meaning it can add acetyl groups to histone proteins. This acetylation generally leads to a more open chromatin structure, which is permissive for gene expression. The p400 subunit, also known as RECQL5, is a core component of this complex and is thought to contribute to its helicase and ATPase activities, which are crucial for its chromatin remodeling function. These activities allow the complex to physically move or displace nucleosomes, further facilitating access to DNA. Dysregulation or mutations in components of the Tip60 complex, including p400, have been implicated in various cellular processes and diseases, such as cancer. Research into the precise roles and interactions of p400 within the Tip60 complex continues to uncover its significance in maintaining genomic stability and regulating gene expression.