p34CDC2

P34CDC2 is a protein-coding gene located on chromosome 19 in humans. It is part of the CDC family of genes, which are involved in cell division and DNA repair. The CDC2 protein, encoded by P34CDC2, is a member of the cyclin-dependent kinase (CDK) family. CDKs are enzymes that regulate the cell cycle by phosphorylating target proteins, thereby controlling processes such as DNA replication, transcription, and cell division.

The P34CDC2 gene is essential for normal cell cycle progression. Mutations in this gene have been associated with various genetic disorders, including cancer. Specifically, alterations in P34CDC2 have been linked to certain types of leukemia and other hematological malignancies. The protein encoded by this gene plays a crucial role in the G2/M phase transition of the cell cycle, where cells prepare for mitosis.

The CDC2 protein forms a complex with cyclin B, which is necessary for its kinase activity. This complex is activated during the G2 phase of the cell cycle and is inactivated during mitosis. The inactivation is mediated by the destruction of cyclin B, which occurs through the action of anaphase-promoting complex (APC) and other regulatory proteins.

Research on P34CDC2 continues to be an active area of study, with ongoing efforts to understand its role in cancer development and potential therapeutic targets for cancer treatment. The gene's involvement in cell cycle regulation makes it a significant target for both basic research and clinical applications.