p150Cac1

p150Cac1 refers to a specific protein, a subunit of the human dynactin complex. Dynactin is a multi-subunit protein complex that functions as an essential cofactor for the cytoplasmic dynein motor protein. Cytoplasmic dynein is responsible for a variety of cellular processes, including intracellular transport, cell division, and muscle contraction. The p150Cac1 subunit, also known as DCTN1, is one of the largest subunits within the dynactin complex. It plays a crucial role in the assembly and function of dynactin, and by extension, dynein-mediated motility.

The p150Cac1 protein has a distinct structure and contains multiple domains that are involved in protein-protein interactions. It is known to interact with other dynactin subunits, as well as with cargo molecules and regulatory proteins. These interactions are vital for correctly targeting dynein to its cellular destinations and for regulating its motor activity. Mutations or alterations in p150Cac1 have been linked to various neurological disorders, including amyotrophic lateral sclerosis (ALS) and Perry syndrome, highlighting its importance in neuronal function and health. Research into p150Cac1 continues to shed light on the intricate mechanisms of intracellular transport and the molecular basis of certain diseases.