oxamniquina
Oxamniquine is an antiparasitic medication used to treat intestinal schistosomiasis caused by Schistosoma mansoni. It was developed in the 1970s and for several decades was a primary treatment in some endemic regions, particularly where praziquantel was less available. Over time its use has declined as praziquantel became the preferred, broad-spectrum therapy.
Mechanism of action and pharmacology: Oxamniquine is considered a prodrug that requires activation by the parasite’s
Spectrum and efficacy: The drug is primarily active against Schistosoma mansoni and shows limited or variable
Safety and contraindications: Common adverse effects include nausea, abdominal discomfort, dizziness, and headaches. Severe hypersensitivity is
Current status: Due to resistance concerns and the widespread adoption of praziquantel, oxamniquine is no longer