nullalleelit
Nullalleelit, also known as null alleles or amorph alleles, are genetic variants that result in a complete loss of function for the gene they are located in. This means that no functional protein is produced from the DNA sequence. Nullalleelit can arise from various mutations, such as deletions that remove the entire gene, frameshift mutations that alter the reading frame and lead to premature termination codons, or nonsense mutations that introduce a premature stop codon. These mutations effectively render the gene non-functional.
The phenotypic consequences of a nullalleeli depend on whether the gene is essential for survival and whether