nectin1

Nectin1, also known as nectin cell adhesion molecule 1, is a protein that plays a crucial role in cell-cell adhesion and the organization of cellular junctions. It belongs to the nectin family of immunoglobulin-like cell adhesion molecules. Nectin1 is a transmembrane glycoprotein that forms homodimers and heterodimers with other nectin family members, such as nectin2.

This protein is predominantly expressed in epithelial and endothelial cells, as well as in the nervous system. Its primary function is to mediate homophilic and heterophilic cell-cell adhesion, contributing to the formation and maintenance of adherens junctions. These junctions are vital for maintaining tissue integrity and regulating cell-cell communication.

Nectin1 is also involved in the establishment of synaptic junctions in neurons, where it plays a role in the proper assembly and function of synapses. In addition to its adhesive properties, nectin1 can participate in signal transduction pathways, influencing cell proliferation, migration, and differentiation. Dysregulation of nectin1 has been implicated in various diseases, including certain types of cancer and neurological disorders, highlighting its importance in cellular homeostasis and development. Its involvement in these processes makes nectin1 a subject of ongoing research in cell biology and disease pathogenesis.

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