myofibroblastiksi
Myofibroblasts are specialized cells that play a crucial role in wound healing and tissue remodeling. They are characterized by expressing both smooth muscle actin and vimentin, proteins typically found in smooth muscle cells and fibroblasts, respectively. This dual expression gives them contractile properties, allowing them to generate force and facilitate wound closure.
These cells are derived from various precursor cells, including resident fibroblasts, pericytes, and bone marrow-derived progenitor
The contractile activity of myofibroblasts is essential for reducing the wound area and initiating tissue repair.
While myofibroblasts are vital for normal healing, their excessive or prolonged activity can lead to pathological