multienzymkomplex
Multienzymkomplex, or multienzyme complex, is a molecular assembly composed of several enzymes that catalyze consecutive steps within a metabolic pathway. These complexes can be highly stable, with enzymes linked on a single scaffold through protein-protein interactions, or dynamic and transient, forming metabolons that assemble and disassemble as needed. By bringing enzymatic activities into close proximity, multienzymkomplexes facilitate substrate channeling, increase reaction throughput, coordinate regulation of pathway flux, and reduce diffusion of labile intermediates. They may also enable shared cofactors and streamlined control of metabolic steps.
Organizationally, multienzymkomplexes can be categorized as stable scaffolded assemblies or transient metabolons. Some are membrane-bound or
Prominent examples include the pyruvate dehydrogenase complex in mitochondria, which couples pyruvate decarboxylation to acetyl-CoA formation
Multienzymkomplexes are relevant for metabolism, cellular regulation, and metabolic engineering. Disruptions can contribute to metabolic disorders,