mineralokortikoidiretseptori

Mineralokortikoidiretseptori, also known as the MR, is a protein that acts as a receptor for mineralocorticoid hormones, primarily aldosterone. These receptors are part of the nuclear receptor superfamily and play a crucial role in regulating electrolyte and water balance in the body. Upon binding to its ligand, aldosterone, the mineralokortikoidiretseptori undergoes a conformational change and translocates to the cell nucleus. There, it binds to specific DNA sequences called hormone response elements, influencing the transcription of target genes. This ultimately leads to increased reabsorption of sodium and secretion of potassium in organs like the kidneys, sweat glands, and salivary glands. The MR is also found in other tissues, including the heart, blood vessels, and brain, where it may have non-classical functions beyond electrolyte homeostasis, such as in inflammation and fibrosis. Dysregulation of the mineralokortikoidiretseptori system is implicated in various diseases, including hypertension, heart failure, and chronic kidney disease. Antagonists of the MR, like spironolactone and eplerenone, are used clinically to treat these conditions by blocking the effects of aldosterone.