malonylCoAs
Malonyl-CoAs, or malonyl coenzyme A derivatives, are thioester compounds that play crucial roles in various biochemical pathways, particularly in fatty acid synthesis and regulation. Structurally, they consist of a malonyl group (a three-carbon unit derived from acetyl-CoA carboxylation) covalently linked to the sulfhydryl group of coenzyme A (CoA). This linkage forms a high-energy thioester bond, which drives energetically unfavorable reactions.
In fatty acid biosynthesis, malonyl-CoA serves as the primary substrate for the enzyme fatty acid synthase
Beyond biosynthesis, malonyl-CoA functions as a regulatory molecule. It inhibits carnitine palmitoyltransferase I (CPT-I), an enzyme
Dysregulation of malonyl-CoA metabolism has been implicated in metabolic disorders, including obesity and diabetes. Elevated malonyl-CoA