macrocarriers

Macrocarriers are a type of virus-like particle that can be engineered to deliver genetic material into cells. They are significantly larger than traditional viral vectors and are derived from large viruses such as adenoviruses or herpesviruses. This larger capacity allows them to carry more genetic information, making them suitable for delivering larger genes or multiple genes simultaneously.

The development of macrocarriers aims to overcome some of the limitations of smaller viral vectors, including payload size constraints and potential immunogenicity. By adapting the structure of existing large viruses, researchers can leverage natural mechanisms for cellular entry and gene expression while modifying them for therapeutic purposes.

Macrocarriers are being explored for various gene therapy applications. Their ability to deliver substantial genetic payloads is particularly advantageous for treating genetic disorders caused by large gene defects or those requiring the introduction of complex genetic circuits. Research is ongoing to optimize their production, safety, and efficiency for clinical use. Challenges include ensuring efficient delivery to target cells, controlling gene expression, and minimizing any potential off-target effects or immune responses.