mTORC1signalvejen
mTORC1 signalvejen, also known as the mechanistic target of rapamycin complex 1 signaling pathway, is a central regulator of cell growth, proliferation, and metabolism. This highly conserved pathway integrates signals from nutrients, growth factors, and cellular energy levels to control protein synthesis, lipid synthesis, and autophagy. The core component of the pathway is the mTOR kinase, which exists in two distinct multiprotein complexes: mTORC1 and mTORC2.
The activation of mTORC1 is primarily driven by the presence of amino acids and growth factors. Amino
Conversely, cellular stresses like nutrient deprivation or low energy levels (indicated by a high AMP:ATP ratio)