mDCs
mDCs, or myeloid dendritic cells, are a crucial component of the innate and adaptive immune systems. They are a type of antigen-presenting cell (APC) that plays a vital role in initiating immune responses. Originating from myeloid progenitor cells in the bone marrow, mDCs circulate in the blood and reside in various tissues, including the skin, mucosa, and lymph nodes. Their primary function is to capture, process, and present antigens to lymphocytes, particularly T cells.
Upon encountering pathogens or foreign substances, mDCs mature and migrate to lymphoid organs. During maturation, they
mDCs are diverse and can be further categorized into subsets based on their surface marker expression and