lipiddominance

Lipiddominance is a concept in biology and biochemistry that refers to the dominance of lipids in the structure and function of biological membranes. This term was coined by S.J. Singer and Garth L. Nicolson in 1972 to describe the idea that lipids play a central role in the organization and function of cell membranes, rather than proteins. Lipids, particularly phospholipids, form the bilayer structure of membranes, which provides a fluid and dynamic environment for embedded proteins to function. The fluid mosaic model, proposed by Singer and Nicolson, emphasizes the importance of lipids in maintaining membrane integrity and facilitating various cellular processes. Lipiddominance highlights the significance of lipid composition and organization in determining membrane properties such as fluidity, permeability, and interaction with other cellular components. Understanding lipiddominance is crucial for studying membrane biology, cell signaling, and various physiological and pathological processes.