leukocytenesterase

Leukocyte esterase, often abbreviated as LE, is an enzyme found within leukocytes, also known as white blood cells. These enzymes are released when white blood cells are present, indicating an inflammatory or infectious process. Specifically, leukocyte esterase is a hydrolase that cleaves ester bonds. Its presence in bodily fluids can be detected through various diagnostic tests. The most common application is in urinalysis, where a positive leukocyte esterase test suggests the presence of white blood cells in the urine, which can be a sign of a urinary tract infection (UTI) or other kidney or bladder conditions. The test typically involves a dipstick that changes color in the presence of the enzyme. The intensity of the color change often correlates with the amount of leukocytes present. While a positive LE test is a sensitive indicator for inflammation, it is not entirely specific and may require further investigation to determine the underlying cause. Other bodily fluids can also be tested for leukocyte esterase, though urinalysis is the most frequent use.