leucoreduction

Leucoreduction is a process used in the preparation of blood components for transfusion, aimed at reducing the number of white blood cells (leukocytes) in the blood product. This procedure is crucial for preventing the transmission of infectious diseases, such as HIV, hepatitis, and other blood-borne pathogens, which can be carried by white blood cells. Leucoreduction can be achieved through various methods, including filtration, washing, and chemical treatment. Filtration involves passing the blood through a filter that retains white blood cells, while washing uses centrifugal force to separate the cells from the red blood cells. Chemical treatment employs agents that selectively destroy white blood cells. The effectiveness of leucoreduction is typically measured by the percentage of white blood cells remaining in the final blood product, with a goal of reducing this percentage to less than 5 x 10^6 per unit of red blood cells. Leucoreduction is an essential step in the production of safe and effective blood components for transfusion, ensuring the health and safety of recipients.