lamininbinding
Laminin-binding refers to interactions between laminin, an extracellular matrix glycoprotein in basement membranes, and cell-surface receptors or other matrix components. Laminin is a heterotrimer with globular domains; laminin-binding drives cell adhesion, migration, differentiation, and tissue organization.
Major laminin-binding receptors include integrins such as α3β1 and α6β4 that recognize laminin in the basement
The glycosylation state of α-dystroglycan is a critical determinant of laminin binding; defects cause muscular dystrophies
In development and tissue homeostasis, laminin-binding supports basement membrane assembly and compartmentalization. Pathological changes in laminin-binding