kroskarmelloosinaatrium

Kroskarmelloosinatrium is a chemical compound used as an excipient in pharmaceutical formulations. It is a chemically modified form of carboxymethylcellulose, a cellulose derivative. The modification involves cross-linking the cellulose chains, which enhances its properties as a disintegrant.

In tablet manufacturing, kroskarmelloosinatrium functions as a superdisintegrant. When a tablet containing this ingredient is ingested, it rapidly absorbs water and swells significantly. This swelling creates internal stresses within the tablet, causing it to break apart into smaller fragments, or disintegrate, much faster than with conventional disintegrants. This enhanced disintegration leads to a quicker release of the active pharmaceutical ingredient (API) into the body, potentially improving drug absorption and bioavailability.

The cross-linking process makes kroskarmelloosinatrium insoluble in water, but its hydrophilic nature allows for rapid water penetration and swelling. It is typically used at low concentrations, ranging from 0.5% to 5% by weight of the tablet. Its effectiveness, stability, and inertness make it a popular choice for a wide range of oral solid dosage forms, including tablets and capsules, where rapid drug dissolution is desired. It is generally considered safe and is widely approved for use in pharmaceuticals globally.