kombinationsterapi
Kombinationsterapi refers to the use of two or more therapeutic modalities, usually medications, in combination to improve outcomes, prevent resistance, or reduce toxicity. It is applied across medical fields, including oncology, infectious diseases, cardiology, and psychiatry. The core idea is that combined treatments can produce greater effect than any single therapy alone, through additive, synergistic, or potentiating interactions.
Rationale and approaches: Combining agents can increase efficacy by targeting multiple pathways, reduce the required dose
Evidence and evaluation: The benefits are established through clinical trials and meta-analyses. Pharmacodynamic and pharmacokinetic considerations,
Risks and challenges: Increased risk of adverse effects, drug–drug interactions, complex dosing, higher costs, and adherence
Examples: HAART for HIV, RIPE therapy for tuberculosis, combination chemotherapy regimens for various cancers, and broad-spectrum
See also: combination therapy, polypharmacy, synergy, isobolography, multi-modality therapy.