koleratoksin
Koleratoksin is a bacterial toxin produced by the bacterium Vibrio cholerae, which is the causative agent of cholera, a severe diarrheal disease. The toxin is responsible for the characteristic symptoms of cholera, including profuse watery diarrhea, which can lead to dehydration and electrolyte imbalance if left untreated. Koleratoksin is an AB toxin, meaning it consists of two distinct subunits: an A subunit, which is the toxic moiety, and a B subunit, which acts as a receptor-binding component.
The A subunit of koleratoksin is an ADP-ribosylating enzyme that targets the Gs alpha subunit of the
The B subunit of koleratoksin binds to the ganglioside GM1 on the surface of intestinal epithelial cells,
Koleratoksin is a potent toxin, with a median lethal dose (LD50) of approximately 10 ng/kg in mice.