koaktiivaattorikompleksit

Koaktiivaattorikompleksit, also known as coactivator complexes, are molecular assemblies that play a crucial role in the regulation of gene expression. These complexes are composed of various proteins that interact with transcription factors, influencing their ability to bind to DNA and regulate gene transcription. Coactivators typically enhance transcription by facilitating the recruitment of the general transcription machinery, such as RNA polymerase II, to the promoter region of a gene. They can also modify chromatin structure, making it more accessible to transcription factors. Examples of coactivators include p300/CBP, which acts as a histone acetyltransferase, and SRC-1, which functions as a histone acetyltransferase and a transcriptional coactivator. Coactivator complexes are essential for the proper functioning of many cellular processes, including development, differentiation, and response to environmental stimuli. Dysregulation of coactivator complexes has been linked to various diseases, such as cancer and metabolic disorders. Understanding the structure and function of coactivator complexes is therefore of great interest in the fields of molecular biology and medicine.