kinaasista
Kinaasista refers to a group of enzymes known as kinases, which play a crucial role in cellular signaling pathways. The term originates from the Greek word *kinēsis*, meaning "movement," reflecting their function in transferring phosphate groups from ATP (adenosine triphosphate) to specific substrates, a process called phosphorylation. This modification often activates or deactivates target proteins, thereby regulating diverse biological processes such as metabolism, cell division, and apoptosis.
Kinases are classified based on their substrate specificity and structural features. The largest and most well-studied
Pharmacological inhibitors targeting kinases have become a cornerstone of modern drug development. For example, imatinib (Gleevec)
Research into kinases continues to expand, driven by advances in structural biology, genomics, and computational modeling.