insulinIGF1

Insulin-like growth factor 1 (IGF1) is a protein that plays a crucial role in growth, development, and metabolism. It is a member of the insulin superfamily and shares structural similarities with insulin and other growth factors. IGF1 is primarily produced by the liver in response to growth hormone (GH) stimulation, although it can also be produced by other tissues such as the brain, muscles, and adipose tissue.

IGF1 exerts its effects through the IGF1 receptor, which is a tyrosine kinase receptor. Upon binding to IGF1, the receptor undergoes autophosphorylation, leading to the activation of downstream signaling pathways that regulate cell proliferation, differentiation, and survival. IGF1 is involved in various physiological processes, including bone growth, muscle development, and tissue repair.

IGF1 levels are tightly regulated and can be influenced by factors such as age, sex, and nutritional status. Inadequate IGF1 levels can lead to growth disorders, such as growth hormone deficiency or IGF1 deficiency, while elevated levels can contribute to conditions like acromegaly, a disorder characterized by excessive growth hormone production.

IGF1 has also been studied for its potential therapeutic applications. It has been used in clinical settings to promote growth in children with growth hormone deficiency and to enhance muscle mass and strength in older adults. However, the use of IGF1 as a therapeutic agent is still a topic of ongoing research and debate, as its long-term effects and potential side effects are not fully understood.