immunoglobulinsuperfamilien
Immunoglobulin superfamilie (IgSF), or immunoglobulin superfamily, refers to a large and diverse group of proteins that share one or more immunoglobulin-like domains in their extracellular region. These domains are typically about 70–110 amino acids long and adopt a beta-sandwich fold. Proteins in the IgSF can be single-pass transmembrane, multi-pass, secreted, or GPI-anchored, and they often function as receptors, ligands, or cell adhesion molecules.
Ig-like domains in the IgSF mediate protein–protein interactions that underlie cell–cell recognition, adhesion, and signaling. The
Representative members include immune system components such as T-cell receptor chains, CD4 and CD8 co-receptors, MHC
Functions of IgSF proteins are diverse but frequently converge on modulating cell contact and signaling. They