iduronate
Iduronate refers to the salt or ester form of iduronic acid, a hexuronic acid that is the C-5 epimer of glucuronic acid. It is a component of several glycosaminoglycans, notably dermatan sulfate, heparan sulfate, and heparin, where iduronate residues contribute to chain conformation and binding properties.
In glycosaminoglycan biosynthesis, glucuronic acid residues can be epimerized to iduronic acid by C5-epimerases, generating iduronate-containing
Biological roles and clinical relevance center on the flexible, sulfated iduronate-rich regions of GAGs, which are
In research and clinical contexts, iduronate residues are used to characterize GAG structure and function. Salts