hypofrakcionált

Hypofractionated is a term used in radiotherapy to describe a treatment schedule where a reduced number of radiation sessions are delivered, with each session containing a higher dose of radiation than in conventionally fractionated treatment. This approach aims to deliver the total prescribed radiation dose over a shorter overall treatment duration.

The rationale behind hypofractionation often stems from the understanding of the biological effects of radiation. Some theories suggest that certain tumors may be more sensitive to larger doses of radiation delivered less frequently, or that the reduced treatment time may allow tumors to proliferate less during the course of therapy. It is also considered for its potential to reduce patient burden and healthcare costs by shortening the overall treatment course.

Hypofractionated regimens are particularly explored for specific cancer types, such as early-stage breast cancer, prostate cancer, and lung cancer. The suitability of hypofractionation depends on various factors, including the tumor's location, size, stage, and radiosensitivity, as well as the patient's overall health. Careful consideration is given to potential side effects, as higher doses per fraction can sometimes lead to increased acute toxicity in surrounding healthy tissues. Clinical trials play a crucial role in establishing the safety and efficacy of different hypofractionated protocols.