highnanomolar

Highnanomolar is an informal term used in biochemistry, pharmacology, and related fields to describe concentrations that fall within the nanomolar (nM) range but are toward the higher end of what is typically observed in a given assay. It is not an official SI unit or standardized measurement, and its exact meaning depends on context and the system under study.

In practice, highnanomolar usually refers to concentrations in the tens to hundreds of nanomolar, and sometimes up to low micromolar (around 1 μM, or 1000 nM), depending on the assay’s sensitivity and the affinity of the interaction being measured. For example, a ligand with an EC50 or IC50 in the ~100 nM range might be described as active or effective at high nanomolar concentrations relative to lower-potency interactions that occur in the picomolar to low-nanomolar range.

Because “high nanomolar” is relative, it is important to report explicit numerical values alongside any qualitative descriptor. When comparing binding affinities or potencies, researchers typically present exact metrics such as EC50, IC50, or Kd with units in nanomolar or micromolar. This ensures clarity across different experimental systems, laboratories, and assay formats.

Overall, highnanomolar serves as a convenient shorthand for a qualitative assessment of potency or concentration that sits near the upper end of the nanomolar scale, without implying a universal threshold.