gyógyszermonitorozással

Gyógyszermonitoring, also known as therapeutic drug monitoring (TDM), is a clinical practice that involves measuring the concentration of certain drugs in a patient's blood or other biological fluids. The primary goal of TDM is to optimize drug therapy by ensuring that drug concentrations remain within a therapeutic range, thereby maximizing efficacy and minimizing toxicity. This practice is particularly useful for drugs with a narrow therapeutic index, where small variations in blood concentration can lead to significant differences in patient response.

The process typically involves collecting a biological sample (e.g., blood) at a specific time relative to drug administration. This sample is then analyzed in a laboratory to determine the drug concentration. The results are interpreted by a healthcare professional, usually a physician or clinical pharmacist, in conjunction with the patient's clinical status, such as symptoms, side effects, and other laboratory values. Based on this comprehensive assessment, adjustments to the drug's dosage, frequency, or even the choice of medication may be recommended.

TDM is frequently employed for a range of medications, including certain antibiotics (e.g., vancomycin, aminoglycosides), antiepileptic drugs (e.g., phenytoin, carbamazepine), immunosuppressants (e.g., cyclosporine, tacrolimus), and anticoagulants (e.g., warfarin). Factors such as patient age, weight, kidney and liver function, and concurrent use of other medications can significantly influence drug pharmacokinetics, making TDM a valuable tool for individualizing treatment regimens and improving patient outcomes.