gp130mediated

gp130-mediated signaling refers to a type of cellular signaling that involves the gp130 protein, a member of the cytokine receptor superfamily. gp130 is a shared receptor subunit that can form heteromeric complexes with other cytokine receptors, enabling the binding and activation of various cytokines. These cytokines include interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin-1 (CT-1), and ciliary neurotrophic factor (CNTF). The binding of these cytokines to their respective receptors results in the activation of gp130, which then initiates a cascade of intracellular signaling events. This signaling pathway is crucial for various physiological processes, including hematopoiesis, immune response, and tissue repair. Dysregulation of gp130-mediated signaling has been implicated in several diseases, such as cancer, inflammation, and autoimmune disorders. Understanding the mechanisms of gp130-mediated signaling is essential for developing targeted therapies for these conditions.