glitazone
Glitazone refers to a class of oral antidiabetic drugs that are also known as thiazolidinediones (TZDs). These medications are used to improve insulin sensitivity in people with type 2 diabetes. Glitazones work by activating specific nuclear receptors called peroxisome proliferator-activated receptors (PPARs), primarily PPAR-gamma, which are involved in regulating glucose and lipid metabolism. By activating PPAR-gamma, glitazones increase the uptake and utilization of glucose in peripheral tissues like muscle and fat, and also reduce hepatic glucose production. This leads to a decrease in blood glucose levels.
The primary glitazone drugs available on the market include pioglitazone and rosiglitazone. They are typically used