florokinolonlar

Florokinolonlar, also known as fluoroquinolones, are a class of broad-spectrum synthetic antimicrobial drugs. They work by inhibiting bacterial DNA replication, transcription, repair, and recombination through targeting essential enzymes called DNA gyrase and topoisomerase IV. This action effectively kills susceptible bacteria.

These drugs are primarily used to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, and certain skin and bone infections. Their effectiveness and convenient oral administration have made them a common choice for many conditions. However, their use is not without potential side effects and concerns regarding the development of antibiotic resistance.

Common side effects can include gastrointestinal issues such as nausea and diarrhea, as well as central nervous system effects like dizziness and headaches. More serious, though less common, side effects can involve tendon rupture, peripheral neuropathy, and cardiac arrhythmias. Due to these potential risks, particularly tendonitis and tendon rupture, fluoroquinolones are often reserved for situations where other antibiotic options are not suitable.

The widespread use of fluoroquinolones has also contributed to the rise of antibiotic resistance, making some infections harder to treat. Therefore, responsible prescribing practices and appropriate patient selection are crucial to preserve the efficacy of this important class of antibiotics.