fibrotisaatioprosessin

Fibrotisaatioprosessi, often referred to as fibrosis, is a pathological process characterized by the excessive accumulation of extracellular matrix, particularly collagen, in an organ or tissue. This deposition disrupts the normal architecture and function of the affected tissue. Fibrosis is a common response to chronic injury, inflammation, or irritation. The exact mechanisms triggering fibrosis can vary depending on the underlying cause but often involve a complex interplay of cellular signaling pathways. Key cell types involved include fibroblasts, myofibroblasts (activated fibroblasts), and inflammatory cells. When tissue damage occurs, these cells are activated to initiate a repair process. In normal healing, this process is tightly regulated and resolves once the injury is repaired. However, in chronic conditions, the fibrotic response becomes dysregulated, leading to persistent activation of fibroblasts and excessive matrix production. This can result in a stiffening and scarring of the tissue, impairing its ability to function. Fibrosis can affect virtually any organ, including the liver (cirrhosis), lungs (pulmonary fibrosis), kidneys (renal fibrosis), and heart (cardiac fibrosis). While some forms of fibrosis are progressive and irreversible, research is ongoing to develop therapies that can prevent, slow, or even reverse fibrotic processes. Treatment strategies often focus on addressing the underlying cause of the injury and inflammation.